1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone
2'-O-methyluridine
CAS: 2140-76-3
Molecular Formula: C10H14N2O6
1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone - Names and Identifiers
| Name | 2'-O-methyluridine |
| Synonyms | 2'-O-METHYLURIDINE 2'-O-methyluridine -2'-O-METHYLURIDINE 2'-O-METHYLURIDINE (CHIRAL) 2''-O-METHYLURIDINE CRYSTALLINE 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione 1-[(2R,3R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHOXYOXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE 1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone |
| CAS | 2140-76-3 |
| EINECS | 2017-001-1 |
| InChI | InChI=1/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1 |
1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone - Physico-chemical Properties
| Molecular Formula | C10H14N2O6 |
| Molar Mass | 258.23 |
| Density | 1.53±0.1 g/cm3(Predicted) |
| Melting Point | 154-156°C |
| Specific Rotation(α) | +40·0 to +44·0°(C=2、H2O) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | White powder |
| Color | White to Off-white |
| Maximum wavelength(λmax) | ['261nm(MeOH)(lit.)'] |
| pKa | 9.39±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.611 |
| MDL | MFCD00056054 |
1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | 26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone - Introduction
2 '-O-methyluridine(2'-O-methyluridine) is an organic compound with the molecular formula C10H14N2O6 and a relative molecular mass of 258.23. It is a derivative of uridine in which the uracil base is substituted with a methoxy group (-OCH3) through the 2 '-site.
2 '-O-methyluridine are widespread in organisms, especially in the core structure of RNA. It plays an important role in the transport, stability and translational regulation of RNA molecules. In addition, it can also be used as a research tool in the biomedical field to study the structure and function of RNA.
There are many methods for preparing 2 '-O-methyluridine, one of which is a common method of reacting uridine with ethyl formate in the presence of sodium borohydride to generate 2'-O-methyluridine.
Regarding safety information, 2 '-O-methyluridine is considered a relatively safe compound under normal conditions of use. However, any compound can be potentially dangerous. Therefore, when using and handling 2 '-O-methyluridine, it is important to follow relevant laboratory safety practices, including wearing protective gloves and glasses. In addition, the compound should be stored and handled properly, avoiding contact with skin or mucous membranes, and away from ignition and oxidizing agents. If ingestion or contact with skin or eyes, seek medical attention immediately.
2 '-O-methyluridine are widespread in organisms, especially in the core structure of RNA. It plays an important role in the transport, stability and translational regulation of RNA molecules. In addition, it can also be used as a research tool in the biomedical field to study the structure and function of RNA.
There are many methods for preparing 2 '-O-methyluridine, one of which is a common method of reacting uridine with ethyl formate in the presence of sodium borohydride to generate 2'-O-methyluridine.
Regarding safety information, 2 '-O-methyluridine is considered a relatively safe compound under normal conditions of use. However, any compound can be potentially dangerous. Therefore, when using and handling 2 '-O-methyluridine, it is important to follow relevant laboratory safety practices, including wearing protective gloves and glasses. In addition, the compound should be stored and handled properly, avoiding contact with skin or mucous membranes, and away from ignition and oxidizing agents. If ingestion or contact with skin or eyes, seek medical attention immediately.
Last Update：2024-04-10 22:29:15
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